Transphobia is a non-clinical term related to the irrational hatred or fear of transsexual/transgender people. Signs of true transphobia in a person include anxiety or anxiety attacks, rapid fear onset, persistent stress, fainting and/or extreme discomfort. Many people labelled as transphobic do not exhibit these symptoms, and the common interpretation of transphobia has changed to denote people who demonstrate a negative attitude toward transsexual or transgender people. As such, the term "transphobia" can be misleading, and in most cases is an invalid analogy of the medical terminology and hence, the term should be used with care.

Examples of Transphobia include Misgendering, Deadnaming and Abinphobia and using slang such as "tranny" when referring to trans people, which may be upsetting to a transgender/transsexual person. Slang terms such as this are is wide usage. Transphobia can also be exhibited through aggression and violence, and the number of crimes related to transphobia is increasing, as seen here.